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Advancing high-throughput gene synthesis technology

Identifieur interne : 002845 ( Main/Exploration ); précédent : 002844; suivant : 002846

Advancing high-throughput gene synthesis technology

Auteurs : Jingdong Tian [États-Unis] ; Kuosheng Ma [États-Unis] ; Ishtiaq Saaem [États-Unis]

Source :

RBID : ISTEX:780EF68B48084F1F6AC6683C66E0B98BBDE26242

English descriptors

Abstract

The emerging field of synthetic biology is generating insatiable demands for synthetic genes, which far exceed existing gene synthesis capabilities. This review discusses the current methods of chemical DNA synthesis and gene assembly, as well as the latest engineering tools, technologies and trends which could potentially lead to breakthroughs in the development of accurate, low-cost and high-throughput gene synthesis technology. The capability of generating unlimited supplies of DNA molecules of any sequence or size will transform biomedical research in the near future.

Url:
DOI: 10.1039/b822268c


Affiliations:


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